Do not miss out on the details about Urolithin A powder 

Urolithin A powder is an interesting compound that has been shown to increase mitochondrial health. Urolithin A powder can be made from ellagitannins in our food by our gut microbiome. However, not everyone can make Urolithin A, and it can also be supplemented.

What is Urolithin A powder?

Urolithin A (UA) is a gut microbiome-derived natural compound that only 40% of people can naturally convert from dietary precursors at meaningful events. Several recent studies have identified positive effects of direct UA administration in health, aging, and age-related conditions.

Experimental models consistently show that UA increases mitophagy and mitochondrial function and blunts excessive inflammatory responses. UA increased biomarkers of mitochondrial function in preclinicalpreclinical models of aging and healthy older adults. UA is a promising strategy to target health and disease conditions of aging, especially those linked to mitochondrial and muscle dysfunction. 

How do we get Urolithin A?

The precursor to Urolithin A powder UA is extranets and their large acids, which are polyphenol. They are available in many foods such as fruits and nuts. About 47% of people have the correct microbes in the gut to convert this into Urolithin A. Scientists are still investigating which microbe species are required.

The alternative is to take Urolic A supplementation, which can be directly absorbed. So, if you can make uric A, where to get it from? Pomegranates are the most famous and best source, but they are also plentiful in raspberries, strawberries, and walnuts. At least 5 glasses of pomegranate juice will be required to generate the equivalent of 500 milligrams of Urolithin A. 

How does Urolithin A work?

Urolithin A most consistent effect is improved mitochondrial health, which is achieved by encouraging mitophagy, the particular form of autophagy that recycles mitochondria. As we get older, mitophagy, just like autophagy, decreases so, restoring it is a good way to restore organ function. Urolithin A has two paths to identify damaged mitochondria and mark them for mitophagy.

They are then transported to the lysosome, absorbed, and broken down. This has been shown in C Elegans mice and humans. The removal of old mitochondria causes the generations a new one. In human trials, there was an increase in the expression of mitochondrial gene sets in the muscles. 

Preclinical Preclinical trials of Urolithin A

Urolithin A power extended lifespan in C Elegans by 45%. Urolithin A was given to mice, which showed enhanced skeletal muscle strength and improved aerobic performance, making sense for improved mitochondrial health. It also increased the voluntary running of mice and rats. Knee treatment with Urolithin A reduced the damage during an ischemic event and improved treated animals’ lipid profiles.

A mouse model of Alzheimer’s reduced amyloid plaques and towel levels, two of the most relevant markers liked to the ad and protected against the effects of strokes. Urolithin A protects against cartilage degeneration, specifically in the case of incontrovertible discs and osteoarthritis and knee joints. It was also shown to reduce pro-inflammatory cytokines in plasma too.